CancerDrs Find care

Head and Neck Cancer clinical trials in South Dakota

12 actively recruiting head and neck cancer trials at 4 sites across South Dakota.

Data from ClinicalTrials.gov · last refreshed

Phase 3 Recruiting Academic/Other

High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer

This phase III trial tests if gabapentin can prevent the need for opiate pain medication for mouth sores (oral mucositis) in patients undergoing treatment with chemotherapy and radiation for squamous cell carcinoma of the head and neck reg…

Sponsor: Alliance for Clinical Trials in Oncology
NCT ID: NCT06992427
Sites in South Dakota:
  • Sanford Cancer Center Oncology Clinic — Sioux Falls, South Dakota
  • Sanford USD Medical Center - Sioux Falls — Sioux Falls, South Dakota
View on ClinicalTrials.gov →
Phase 3 Recruiting NIH

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

This phase III trial compares the effect of adding cetuximab to pembrolizumab versus pembrolizumab alone in treating patients with head and neck squamous cell carcinoma (HNSCC) that has come back after a period of improvement (recurrent) a…

Sponsor: National Cancer Institute (NCI)
NCT ID: NCT06589804
Sites in South Dakota:
  • Avera Cancer Institute - Mitchell — Mitchell, South Dakota
  • Avera Cancer Institute at Pierre — Pierre, South Dakota
  • Sanford Cancer Center Oncology Clinic — Sioux Falls, South Dakota
  • Avera Cancer Institute — Sioux Falls, South Dakota
  • Sanford USD Medical Center - Sioux Falls — Sioux Falls, South Dakota
View on ClinicalTrials.gov →
Phase 2, Phase 3 Recruiting Academic/Other

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

This phase II/III trial studies how well sentinel lymph node biopsy works and compares sentinel lymph node biopsy surgery to standard neck dissection as part of the treatment for early-stage oral cavity cancer. Sentinel lymph node biopsy s…

Sponsor: NRG Oncology
NCT ID: NCT04333537
Sites in South Dakota:
  • Sanford Cancer Center Oncology Clinic — Sioux Falls, South Dakota
  • Avera Cancer Institute — Sioux Falls, South Dakota
  • Sanford USD Medical Center - Sioux Falls — Sioux Falls, South Dakota
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

A Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab in First-line Treatment of Locoregional Recurrent Squamous Cell Carcinoma of the Head and Neck With No Distant Metastases

The goal of this clinical trial is to learn if ASP-1929 photoimmunotherapy (PIT) in combination with pembrolizumab works to treat recurrent squamous cell cancer of the head and neck (HNSCC) with no distant metastases. It will also learn ab…

Sponsor: Rakuten Medical, Inc.
NCT ID: NCT06699212
Sites in South Dakota:
  • Avera Cancer Institute — Sioux Falls, South Dakota
View on ClinicalTrials.gov →
Phase 2 Recruiting Network

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

This phase II trial studies how well radiation therapy with or without cisplatin works in treating patients with stage III-IVA squamous cell carcinoma of the head and neck who have undergone surgery. Radiation therapy uses high energy x-ra…

Sponsor: ECOG-ACRIN Cancer Research Group
NCT ID: NCT02734537
Sites in South Dakota:
  • Sanford Cancer Center Oncology Clinic — Sioux Falls, South Dakota
  • Avera Cancer Institute — Sioux Falls, South Dakota
  • Sanford USD Medical Center - Sioux Falls — Sioux Falls, South Dakota
View on ClinicalTrials.gov →
Phase 2 Recruiting NIH

Testing Nivolumab and Ipilimumab Immunotherapy With or Without the Targeted Drug Cabozantinib in Recurrent, Metastatic, or Incurable Nasopharyngeal Cancer

This phase II trial tests how well nivolumab and ipilimumab immunotherapy with or without cabozantinib works in treating patients with nasopharyngeal cancer that has come back (after a period of improvement) (recurrent), has spread from wh…

Sponsor: National Cancer Institute (NCI)
NCT ID: NCT05904080
Sites in South Dakota:
  • Sanford Cancer Center Oncology Clinic — Sioux Falls, South Dakota
  • Sanford USD Medical Center - Sioux Falls — Sioux Falls, South Dakota
View on ClinicalTrials.gov →
Phase 2 Recruiting NIH

A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)

This phase II trial tests effects of nivolumab in combination with chemotherapy drugs prior to radiation therapy patients with nasopharyngeal carcinoma (NPC). Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's…

Sponsor: National Cancer Institute (NCI)
NCT ID: NCT06064097
Sites in South Dakota:
  • Sanford USD Medical Center - Sioux Falls — Sioux Falls, South Dakota
View on ClinicalTrials.gov →
Phase 2 Recruiting Industry

Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors

A prospective, open-label, multi-cohort, non-randomized, multicenter Phase 2 study evaluating adoptive cell therapy (ACT) with TIL \[LN-144/LN-145 (lifileucel)\] in combination with immune checkpoint inhibitors or TIL \[LN-144/LN-145 (lifi…

Sponsor: Iovance Biotherapeutics, Inc.
NCT ID: NCT03645928
Sites in South Dakota:
  • Avera Cancer Institute — Sioux Falls, South Dakota
View on ClinicalTrials.gov →
Phase 1 Recruiting Industry

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

This trial will look at a drug called sigvotatug vedotin (SGN-B6A) alone and with pembrolizumab, with or without chemotherapy, to find out whether it is safe for people who have solid tumors. It will study sigvotatug vedotin to find out wh…

Sponsor: Seagen, a wholly owned subsidiary of Pfizer
NCT ID: NCT04389632
Sites in South Dakota:
  • Sanford Cancer Center — Sioux Falls, South Dakota
  • Sanford Research — Sioux Falls, South Dakota
  • Sanford USD Medical Center — Sioux Falls, South Dakota
View on ClinicalTrials.gov →
Recruiting Academic/Other

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

This study collects blood and tissue samples from patients with cancer and without cancer to evaluate tests for early cancer detection. Collecting and storing samples of blood and tissue from patients with and without cancer to study in th…

Sponsor: Alliance for Clinical Trials in Oncology
NCT ID: NCT05334069
Sites in South Dakota:
  • Sanford Cancer Center Oncology Clinic — Sioux Falls, South Dakota
  • Sanford USD Medical Center - Sioux Falls — Sioux Falls, South Dakota
View on ClinicalTrials.gov →

Medical disclaimer: This page aggregates public ClinicalTrials.gov data. It is not medical advice. Always confirm eligibility and enrollment details with the trial site or your oncologist.

Source: ClinicalTrials.gov API v2 · Last checked: 2026-04-20