Leukemia clinical trials in Illinois

41 actively recruiting leukemia trials at 63 sites across Illinois.

Data from ClinicalTrials.gov · last refreshed 2026-10-12

Payments from drug makers to the doctors running these trials

For 1 of the trials on this page, the pharmaceutical company funding the trial also disclosed payments to the physicians leading it — public data from the federal CMS Open Payments database. Paying clinical-trial investigators for site work is expected and necessary for industry-funded trials; the scale and source are simply useful context when you're deciding whether to enroll. See the full leukemia transparency page →

Payments from the drug maker running this trial to its lead doctors

CMS Open Payments · 2024

AbbVie funds and runs this clinical trial (NCT06428019). In 2024, AbbVie reported paying the doctors leading the trial a total of $247,582 for research work on this study.

Who paid

ABBVIE INC. $247,582

Paid for research work on this trial

FARRUKH AWAN(oncologist on CancerDrs) $53,750
BRUCE CHESON(oncologist on CancerDrs) $51,969
ARI PELCOVITS $33,090
PREET SINGH(oncologist on CancerDrs) $32,190
SHALIN KOTHARI(oncologist on CancerDrs) $24,500

Questions a patient might reasonably ask

Who is funding this trial, and how does the funding company stand to benefit if the trial succeeds?
Does my oncologist have a financial relationship with the trial sponsor outside of this trial?
Are there non-industry-sponsored trials (NIH, cooperative group) for my condition I should consider?
What are the alternative standards of care I should compare against enrolling here?

Research payments are not, by themselves, a conflict — paying for legitimate trial work is how drug development gets funded. The purpose of Sunshine Act disclosure is to give patients the context, not to make the decision for them.

Source: CMS Open Payments · ClinicalTrials.gov · Dispute process · How we compute this

As displayed on 2026-04-21. Corrections flow from the manufacturer through CMS and are adopted on our next refresh.

Phase 3 Recruiting NIH

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

This phase III trial compares early treatment with venetoclax and obinutuzumab versus delayed treatment with venetoclax and obinutuzumab in patients with newly diagnosed high-risk chronic lymphocytic leukemia or small lymphocytic lymphoma.…

Sponsor: National Cancer Institute (NCI)

NCT ID: NCT04269902

Sites in Illinois:

OSF Saint Anthony's Health Center — Alton, Illinois
Rush-Copley Medical Center — Aurora, Illinois
Illinois CancerCare-Bloomington — Bloomington, Illinois
Loyola Center for Health at Burr Ridge — Burr Ridge, Illinois
Illinois CancerCare-Canton — Canton, Illinois

View on ClinicalTrials.gov →

Phase 3 Recruiting Academic/Other

Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia

This phase III trial studies the side effects of inotuzumab ozogamicin and how well it works when given with frontline chemotherapy in treating patients with newly diagnosed B acute lymphoblastic leukemia. Inotuzumab ozogamicin is a monocl…

Sponsor: Alliance for Clinical Trials in Oncology

NCT ID: NCT03150693

Sites in Illinois:

OSF Saint Anthony's Health Center — Alton, Illinois
Loyola Center for Health at Burr Ridge — Burr Ridge, Illinois
Northwestern University — Chicago, Illinois
Rush MD Anderson Cancer Center — Chicago, Illinois
University of Illinois — Chicago, Illinois

View on ClinicalTrials.gov →

Phase 3 Recruiting Academic/Other

Testing the Addition of Anti-Cancer Drug Sonrotoclax, to the Standard Treatment Zanubrutinib, for Previously Untreated CLL/SLL

This phase III trial compares the effect of adding sonrotoclax to zanubrutinib versus zanubrutinib alone for the treatment of patients with untreated chronic lymphoblastic leukemia (CLL)/small lymphocytic lymphoma (SLL). Sonrotoclax is in …

Sponsor: Alliance for Clinical Trials in Oncology

NCT ID: NCT07321652

Sites in Illinois:

Illinois CancerCare-Bloomington — Bloomington, Illinois
Illinois CancerCare-Canton — Canton, Illinois
Illinois CancerCare-Carthage — Carthage, Illinois
Northwestern University — Chicago, Illinois
University of Illinois — Chicago, Illinois

View on ClinicalTrials.gov →

Phase 3 Recruiting Network

A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

This phase III trial compares standard chemotherapy to therapy with liposome-encapsulated daunorubicin-cytarabine (CPX-351) and/or gilteritinib for patients with newly diagnosed acute myeloid leukemia with or without FLT3 mutations. Drugs …

Sponsor: Children's Oncology Group

NCT ID: NCT04293562

Sites in Illinois:

Lurie Children's Hospital-Chicago — Chicago, Illinois
University of Illinois — Chicago, Illinois
University of Chicago Comprehensive Cancer Center — Chicago, Illinois
Loyola University Medical Center — Maywood, Illinois
Advocate Children's Hospital-Oak Lawn — Oak Lawn, Illinois

View on ClinicalTrials.gov →

Phase 3 Recruiting Industry

A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)

The purpose of this study is to assess how bleximenib and Venetoclax (VEN)+ Azacitidine (AZA) works as compared to placebo and VEN+AZA alone for the treatment of participants with newly diagnosed Acute Myeloid Leukemia (AML) with a mutatio…

Sponsor: Janssen Research & Development, LLC

NCT ID: NCT06852222

Sites in Illinois:

University of Chicago Medicine — Chicago, Illinois
Illinois Cancer Specialists — Niles, Illinois

View on ClinicalTrials.gov →

Phase 3 Recruiting Industry

Study of Olverembatinib (HQP1351) in Patients With CML-CP

Study comparing efficacy and safety of olverembatinib (investigational arm) vs. bosutinib (control arm) in patients with CML-CP (Part A). Study will also evaluate efficacy and safety of olverembatinib (single-arm) in CML-CP patients with T…

Sponsor: Ascentage Pharma Group Inc.

NCT ID: NCT06423911

Sites in Illinois:

Ascentage Investigative Site #1055 — Chicago, Illinois
Ascentage Investigative Site #1095 — Decatur, Illinois

View on ClinicalTrials.gov →

Phase 3 Recruiting Industry

A Study to Evaluate the Safety and Efficacy of Tacabrutideg (BGB-16673) Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

The purpose of this study is to evaluate the efficacy and safety of tacabrutideg alone compared with pirtobrutinib in patients with relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who had…

Sponsor: BeOne Medicines

NCT ID: NCT06973187

Sites in Illinois:

University of Chicago Medical Center — Chicago, Illinois

View on ClinicalTrials.gov →

Phase 3 Recruiting Network

Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With Acute Myeloid Leukemia

This phase III trial compares the effect of xylitol dental wipes to dental wipes without xylitol for the reduction of bloodstream infection in children with acute myeloid leukemia (AML). Xylitol is a naturally occurring sugar compound foun…

Sponsor: Children's Oncology Group

NCT ID: NCT07022678

Sites in Illinois:

Lurie Children's Hospital-Chicago — Chicago, Illinois

View on ClinicalTrials.gov →

Phase 3 Recruiting Industry

A Study to Evaluate the Risk of Tumor Lysis Syndrome (TLS) in Adult Participants Receiving Oral Venetoclax in Combination With Intravenously Infused Obinutuzumab or Oral Acalabrutinib for Previously Untreated Chronic Lymphocytic Leukemia (CLL)

Chronic lymphocytic leukemia (CLL) is the most common leukemia (cancer of blood cells). The purpose of this study is to assess the safety of venetoclax in combination with obinutuzumab or acalabrutinib in the treatment of CLL. Adverse even…

Sponsor: AbbVie

NCT ID: NCT06428019

Sites in Illinois:

Springfield Clinic - First /ID# 270145 — Springfield, Illinois

View on ClinicalTrials.gov →

Phase 3 Recruiting Industry

ROCKET-CLL Global Phase 3 Study: Rocbrutinib vs Pirtobrutinib in cBTKi-Pretreated R/R CLL/SLL

This is a Phase 3, randomized, open-label, multicenter study comparing rocbrutinib (LP-168) versus pirtobrutinib in adult participants with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who h…

Sponsor: Newave Pharmaceutical Inc

NCT ID: NCT07342478

Sites in Illinois:

Orchard Healthcare Research — Skokie, Illinois

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Phase 2 Recruiting NIH

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

This MyeloMATCH Master Screening and Reassessment Protocol (MSRP) evaluates the use of a screening tool and specific laboratory tests to help improve participants' ability to register to clinical trials throughout the course of their myelo…

Sponsor: National Cancer Institute (NCI)

NCT ID: NCT05564390

Sites in Illinois:

Advocate Outpatient Center - Aurora — Aurora, Illinois
Advocate Good Shepherd Hospital — Barrington, Illinois
OSF Saint Joseph Medical Center — Bloomington, Illinois
Illinois CancerCare-Bloomington — Bloomington, Illinois
Illinois CancerCare-Canton — Canton, Illinois

View on ClinicalTrials.gov →

Phase 2 Recruiting NIH

Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)

This phase II MyeloMATCH treatment trial compares the usual treatment of azacitidine and venetoclax to the combination treatment of azacitidine, venetoclax and gilteritinib in treating older and unfit patients with acute myeloid leukemia a…

Sponsor: National Cancer Institute (NCI)

NCT ID: NCT06317649

Sites in Illinois:

Northwestern University — Chicago, Illinois
University of Illinois — Chicago, Illinois
University of Chicago Comprehensive Cancer Center — Chicago, Illinois
Carle at The Riverfront — Danville, Illinois
Cancer Care Specialists of Illinois - Decatur — Decatur, Illinois

View on ClinicalTrials.gov →

Phase 2 Recruiting NIH

Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)

This phase II MyeloMATCH treatment trial compares cytarabine with daunorubicin versus cytarabine with daunorubicin and venetoclax versus venetoclax with azacitidine for the treatment of younger patients with intermediate risk acute myeloid…

Sponsor: National Cancer Institute (NCI)

NCT ID: NCT05554393

Sites in Illinois:

Centralia Oncology Clinic — Centralia, Illinois
Northwestern University — Chicago, Illinois
University of Chicago Comprehensive Cancer Center — Chicago, Illinois
Cancer Care Specialists of Illinois - Decatur — Decatur, Illinois
Decatur Memorial Hospital — Decatur, Illinois

View on ClinicalTrials.gov →

Phase 2 Recruiting NIH

Comparing New Treatments for People With Newly Diagnosed Acute Myeloid Leukemia That Has an IDH2 Gene Change (A MyeloMATCH Treatment Trial)

This phase II MyeloMATCH treatment trial studies how well ASTX727 and venetoclax plus enasidenib works compared to ASTX727 and venetoclax alone for the treatment of older patients with newly diagnosed acute myeloid leukemia (AML) or younge…

Sponsor: National Cancer Institute (NCI)

NCT ID: NCT06672146

Sites in Illinois:

Northwestern University — Chicago, Illinois
University of Illinois — Chicago, Illinois
University of Chicago Comprehensive Cancer Center — Chicago, Illinois
Northwestern Medicine Cancer Center Kishwaukee — DeKalb, Illinois
NorthShore University HealthSystem-Evanston Hospital — Evanston, Illinois

View on ClinicalTrials.gov →

Phase 2 Recruiting NIH

Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia

This phase II trial tests the addition of venetoclax and/or blinatumomab to usual chemotherapy for treating infants with newly diagnosed acute lymphoblastic leukemia (ALL) with a KMT2A gene rearrangement (KMT2A-rearranged \[R\]) or without…

Sponsor: National Cancer Institute (NCI)

NCT ID: NCT06317662

Sites in Illinois:

Lurie Children's Hospital-Chicago — Chicago, Illinois
University of Chicago Comprehensive Cancer Center — Chicago, Illinois
Advocate Children's Hospital-Oak Lawn — Oak Lawn, Illinois
Advocate Children's Hospital-Park Ridge — Park Ridge, Illinois
OSF Children's Hospital of Illinois — Peoria, Illinois

View on ClinicalTrials.gov →

Phase 2 Recruiting NIH

Testing the Addition of Venetoclax or Gemtuzumab Ozogamicin (GO) to Usual Treatment Regimen (Cytarabine and Daunorubicin, "7+3") for Core Binding Factor Acute Myeloid Leukemia (CBF-AML) to Improve Response (A MYELOMATCH Treatment Trial)

This phase II MYELOMATCH treatment trial compares the effect of venetoclax to gemtuzumab ozogamicin, when given with cytarabine and daunorubicin ("7+3" regimen), for the treatment of patients with core binding factor acute myeloid leukemia…

Sponsor: National Cancer Institute (NCI)

NCT ID: NCT06917911

Sites in Illinois:

Northwestern University — Chicago, Illinois

View on ClinicalTrials.gov →

Phase 2 Recruiting NIH

Comparing Different Treatment Lengths for Venetoclax in Older People With Newly Diagnosed Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial)

This phase II MyeloMATCH treatment trial compares ASTX727 with standard duration versus shorter duration of venetoclax for the treatment of newly diagnosed acute myeloid leukemia (AML). ASTX727 is a combination of decitabine and cedazuridi…

Sponsor: National Cancer Institute (NCI)

NCT ID: NCT07437950

Sites in Illinois:

Illinois CancerCare-Bloomington — Bloomington, Illinois
Illinois CancerCare-Canton — Canton, Illinois
Illinois CancerCare-Carthage — Carthage, Illinois
Cancer Care Specialists of Illinois - Decatur — Decatur, Illinois
Decatur Memorial Hospital — Decatur, Illinois

View on ClinicalTrials.gov →

Phase 1, Phase 2 Recruiting Academic/Other

A Phase I/II Study of Trametinib and Azacitidine for Patients With Newly Diagnosed Juvenile Myelomonocytic Leukemia

This clinical trial will test the safety and efficacy of combining trametinib and azacitidine in patients with juvenile myelomonocytic leukemia (JMML). Newly diagnosed lower-risk JMML patients will receive trametinib and azacitidine. High-…

Sponsor: Therapeutic Advances in Childhood Leukemia Consortium

NCT ID: NCT05849662

Sites in Illinois:

Lurie Children's Hospital of Chicago — Chicago, Illinois

View on ClinicalTrials.gov →

Phase 1, Phase 2 Recruiting Industry

The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies

This is an open-label, Phase 1/2 study designed to characterize the safety, tolerability, Pharmacokinetics(PK), and preliminary antitumor activity of AVM0703 administered as a single intravenous (IV) infusion to patients with lymphoid mali…

Sponsor: AVM Biotechnology Inc

NCT ID: NCT04329728

Sites in Illinois:

University of Illinois at Chicago Cancer Center — Chicago, Illinois

View on ClinicalTrials.gov →

Phase 1, Phase 2 Recruiting Industry

A Study of CTD402 in T-ALL/LBL Patients

The goal of the TENACITY-01 clinical trial is to learn if CTD402 UCART is safe and effective for relapsed/refractory T-ALL/LBL patients. Participants with relapsed/refractory T-ALL/LBL over the age of 1 year will be eligible to participate…

Sponsor: Imviva Bio

NCT ID: NCT07070219

Sites in Illinois:

University of Chicago — Chicago, Illinois

View on ClinicalTrials.gov →

Phase 1, Phase 2 Recruiting Industry

Study of AZD3632 Monotherapy or in Combination With Anticancer Agents in Participants With Advanced Haematologic Malignancies With KMT2Ar, NPM1m, or Other Genotypes Associated With HOX Overexpression

The purpose of this study is to understand the safety, tolerability, efficacy, pharmacokinetic (PK), pharmacodynamic (PD), and preliminary efficacy of orally administered AZD3632 in participants with advanced haematologic malignancies with…

Sponsor: AstraZeneca

NCT ID: NCT07155226

Sites in Illinois:

Research Site — Decatur, Illinois

View on ClinicalTrials.gov →

Phase 1, Phase 2 Recruiting Academic/Other

A Study to Investigate LP-118, Ponatinib, Vincristine and Dexamethasone in Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LBL)

The purpose of this study is to learn more about LP-118 (an experimental drug) and its side effects and decide on acceptable doses. The purpose of this study is to determine if LP-118 can be given safely with another medicine called ponati…

Sponsor: University of Chicago

NCT ID: NCT06207123

Sites in Illinois:

University of Chicago Medicine Comprehensive Cancer Center — Chicago, Illinois

View on ClinicalTrials.gov →

Phase 2 Recruiting Academic/Other

Intensity Modulated Total Marrow Irradiation in Fully Human Leukocyte Antigen (HLA)-Matched and Partially-HLA Mismatched Allogeneic Transplantation Patients With High-Risk Acute Myeloid Leukemia (AML), Chronic Myeloid Leukemia (CML), and Myelodysplastic Syndrome (MDS)

The study is a Phase II clinical trial. Patients will receive intensity-modulated total marrow irradiation (TMI) at a dose of 9 Gray (Gy) with standard myeloablative fludarabine intravenous (IV) and targeted busulfan (FluBu4) conditioning …

Sponsor: University of Illinois at Chicago

NCT ID: NCT06802315

Sites in Illinois:

University of Illinois Cancer Center — Chicago, Illinois

View on ClinicalTrials.gov →

Phase 2 Recruiting Academic/Other

Study of Chemotherapy-Free Induction Regimen for Ph+ Acute Lymphoblastic Leukemia With Inotuzumab Ozogamicin (InO)

This research study will add an anti-cancer drug (called inotuzumab ozogamicin also known as "InO") to treatment for participants with newly diagnosed Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). Doctors leadi…

Sponsor: University of Chicago

NCT ID: NCT04747912

Sites in Illinois:

University of Chicago Medical Center — Chicago, Illinois

View on ClinicalTrials.gov →

Phase 1 Recruiting Industry

A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML

Ziftomenib is an investigational drug in development for the treatment of patients with acute myeloid leukemia (AML) with certain genetic alterations. This protocol has 3 separate arms that will investigate the benefits and risks of adding…

Sponsor: Kura Oncology, Inc.

NCT ID: NCT05735184

Sites in Illinois:

Robert H. Lurie Comprehensive Cancer Center of Northwestern University — Chicago, Illinois
Loyola University Medical Center — Maywood, Illinois

View on ClinicalTrials.gov →

Showing 25 of 41 trials with sites in Illinois. See all leukemia trials →

Medical disclaimer: This page aggregates public ClinicalTrials.gov data. It is not medical advice. Always confirm eligibility and enrollment details with the trial site or your oncologist.

Source: ClinicalTrials.gov API v2 · Last checked: 2026-10-12