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Liver Cancer clinical trials in Florida

44 actively recruiting liver cancer trials at 27 sites across Florida.

Data from ClinicalTrials.gov · last refreshed

Phase 3 Recruiting Industry

Phase III Study of Rilvegostomig in Combination With Bevacizumab With or Without Tremelimumab as First-line Treatment of Hepatocellular Carcinoma

This is a Phase III, randomised, open-label, sponsor-blinded, 3-arm, multicentre, global study assessing the efficacy and safety of rilvegostomig in combination with bevacizumab with or without tremelimumab compared to atezolizumab in comb…

Sponsor: AstraZeneca
NCT ID: NCT06921785
Sites in Florida:
  • Research Site — Jacksonville, Florida
View on ClinicalTrials.gov →
Phase 2 Recruiting Industry

A Study Evaluating Atezolizumab, With or Without Bevacizumab, in Participants With Unresectable Hepatocellular Carcinoma and Child-pugh B7 and B8 Cirrhosis

The purpose of this study is to assess the safety of atezolizumab and bevacizumab, or atezolizumab alone, as first-line treatment in participants with unresectable, locally advanced or metastatic hepatocellular carcinoma (HCC) with Child-p…

Sponsor: Genentech, Inc.
NCT ID: NCT06096779
Sites in Florida:
  • Orlando Health Inc. — Orlando, Florida
View on ClinicalTrials.gov →
Phase 2 Recruiting NIH

Testing the Combination of the Anticancer Drug Durvalumab With Chemotherapy (Gemcitabine and Cisplatin) at Improving Outcomes for High-Risk Resectable Liver Cancer Before Surgery

This phase II trial tests how well giving durvalumab with standard chemotherapy, gemcitabine and cisplatin, before surgery works in treating patients with high risk liver cancer (cholangiocarcinoma) that can be removed by surgery (resectab…

Sponsor: National Cancer Institute (NCI)
NCT ID: NCT06050252
Sites in Florida:
  • UF Health Cancer Institute - Gainesville — Gainesville, Florida
View on ClinicalTrials.gov →
Phase 1, Phase 2 Recruiting Industry

A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors

This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1303/BNT323 in subjects with advanced solid tumors that express HER2.

Sponsor: DualityBio Inc.
NCT ID: NCT05150691
Sites in Florida:
  • Advanced Research LLC — Coral Springs, Florida
  • The Oncology Institute of Hope and Innovation — Lakeland, Florida
  • D&H Cancer Research Center LLC — Margate, Florida
  • HCA Mercy Hospital — Miami, Florida
  • BRCR Medical Center Inc. — Plantation, Florida
View on ClinicalTrials.gov →
Phase 1, Phase 2 Recruiting Industry

A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors

This is a dose-escalation and dose-expansion Phase 1/2a trial to evaluate the safety and tolerability of DB-1311/BNT324 in subjects with advanced solid tumors.

Sponsor: DualityBio Inc.
NCT ID: NCT05914116
Sites in Florida:
  • Research Site 118 — Celebration, Florida
  • Research Site 127 — Margate, Florida
  • Research Site 137 — Orlando, Florida
  • Research Site 101 — Plantation, Florida
  • Research Site 109 — Tamarac, Florida
View on ClinicalTrials.gov →
Phase 1, Phase 2 Recruiting Industry

A Study of TTI-101 as Monotherapy and in Combination in Participants With Locally Advanced or Metastatic, and Unresectable Hepatocellular Carcinoma

The primary objectives of Cohort A Phase 1b and exploratory expansion are to evaluate the safety and tolerability of TTI-101 orally administered as a single agent to participants with locally advanced or metastatic, and unresectable Hepato…

Sponsor: Tvardi Therapeutics, Incorporated
NCT ID: NCT05440708
Sites in Florida:
  • Moffitt Cancer Center — Tampa, Florida
View on ClinicalTrials.gov →
Phase 2 Recruiting Academic/Other

Atezolizumab in Combination With a Multi-Kinase Inhibitor for the Treatment of Unresectable, Locally Advanced, or Metastatic Liver Cancer

This phase II trial tests whether atezolizumab in combination with a multi-kinase inhibitor (cabozantinib or lenvatinib) compared to multi-kinase inhibitor alone in treating patients with liver cancer that cannot be removed by surgery (unr…

Sponsor: Academic and Community Cancer Research United
NCT ID: NCT05168163
Sites in Florida:
  • Mayo Clinic in Florida — Jacksonville, Florida
  • Cleveland Clinic Weston Florida — Weston, Florida
View on ClinicalTrials.gov →
Phase 1, Phase 2 Recruiting Industry

Study of the Theranostic Pair RYZ811 (Diagnostic) and RYZ801 (Therapeutic) to Identify and Treat Subjects With GPC3+ (Glypican-3) Unresectable HCC

Phase 1/2 randomized, controlled, open-label trial of theranostic pair RYZ811 (diagnostic) and RYZ801 (therapeutic) to identify and treat subjects with GPC3+ unresectable hepatocellular carcinoma (HCC)

Sponsor: RayzeBio, Inc.
NCT ID: NCT06726161
Sites in Florida:
  • Research Facility — Jacksonville, Florida
View on ClinicalTrials.gov →
Phase 2 Recruiting Industry

Study of RP2 in Combination With Second-line Therapy in Patients With Locally Advanced or Metastatic HCC

The purpose of this study is to assess the efficacy and safety of RP2 in combination with atezolizumab plus bevacizumab (Cohorts 1a and 1b) and RP2 monotherapy (Cohort 2) in the as second line treatment in patients with locally advanced un…

Sponsor: Replimune, Inc.
NCT ID: NCT05733598
Sites in Florida:
  • Sylvester Comprehensive Cancer Center (University of Miami Hospital and Clinics) — Miami, Florida
  • Moffitt Cancer Center — Tampa, Florida
View on ClinicalTrials.gov →
Phase 2 Recruiting Industry

Study of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer

GEMINI-Hepatobiliary study will assess the efficacy, safety and tolerability of novel immunomodulators alone and in combination with other anticancer drugs in participants with specified advanced solid tumors.

Sponsor: AstraZeneca
NCT ID: NCT05775159
Sites in Florida:
  • Research Site — Miami Beach, Florida
View on ClinicalTrials.gov →
Phase 1, Phase 2 Recruiting Industry

A Study of Tegavivint (BC2059) in Patients With Advanced Hepatocellular Carcinoma

This study will be conducted in 2 parts. The first part is a phase 1 single-agent dose escalation, and dose optimization, study of tegavivint in patients with advanced HCC after failure of at least one line of prior systemic therapy. The s…

Sponsor: Iterion Therapeutics
NCT ID: NCT05797805
Sites in Florida:
  • Sylvester Comprehensive Cancer Center — Miami, Florida
View on ClinicalTrials.gov →
Phase 1, Phase 2 Recruiting Industry

A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy

This study is an open-label Phase Ib (Part A) dose escalation followed by a blinded, randomized, multi cohort Phase 2a (Part B) comparison of combination vs. reference regimens. Currently study will only be enrolling the Phase 1b and the P…

Sponsor: 7 Hills Pharma, LLC
NCT ID: NCT06362369
Sites in Florida:
  • Florida Cancer Specialists — Lake Mary, Florida
View on ClinicalTrials.gov →
Phase 1, Phase 2 Recruiting Industry

A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and therapeutic activity of GI-102 as a single agent and in combination with conventional anti-cancer drugs, pembrolizumab or trastuzumab deruxtecan(T-DXd…

Sponsor: GI Innovation, Inc.
NCT ID: NCT05824975
Sites in Florida:
  • Mayo Clinic in Florida — Jacksonville, Florida
View on ClinicalTrials.gov →
Phase 2 Recruiting Industry

An Open-Label, Multiple-Center, Phase IIa/IIb Clinical Trial to Evaluate the Efficacy, Safety and Tolerability of VG161 as Monotherapy and in Combination With Nivolumab for Treatment of Patients With Hepatocellular Carcinoma or Intrahepatic Cholangiocarcinoma

Safety Run-in Cohort (cohort 1): 10 patients will be treated with IT injection of VG161 in the cohort 1 at dose level of 1.0x10E8 PFU x 3 days. Monotherapy Cohorts (Cohort 2 and 3) Cohort 2 (HCC) This part is a single-agent, single one-dos…

Sponsor: Virogin Biotech Canada Ltd
NCT ID: NCT05223816
Sites in Florida:
  • Mayo Clinic Florida — Jacksonville, Florida
View on ClinicalTrials.gov →
Phase 2 Recruiting Academic/Other

At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer

This clinical trial studies the effect of cancer directed therapy given at-home versus in the clinic for patients with cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (adv…

Sponsor: Mayo Clinic
NCT ID: NCT05969860
Sites in Florida:
  • Mayo Clinic in Florida — Jacksonville, Florida
View on ClinicalTrials.gov →
Phase 2 Recruiting Academic/Other

Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program

This phase II trial compares the impact of subcutaneous (SC) nivolumab given in an in-home setting to an in-clinic setting on cancer care and quality of life. Currently, most drug-related cancer care is conducted in clinic type centers or …

Sponsor: Mayo Clinic
NCT ID: NCT06265285
Sites in Florida:
  • Mayo Clinic in Florida — Jacksonville, Florida
View on ClinicalTrials.gov →
Phase 2 Recruiting Academic/Other

AD HOC Trial: Artificial Intelligence-Based Drug Dosing In Hepatocellular Carcinoma

This study will test the hypothesis that a novel combination of three drugs (sorafenib, sonidegib, and irinotecan), in conjunction with individually optimized doses, can be safely administered and lead to improved clinical outcomes in pati…

Sponsor: University of Florida
NCT ID: NCT05669339
Sites in Florida:
  • University of Florida — Gainesville, Florida
View on ClinicalTrials.gov →
Phase 2 Recruiting Academic/Other

The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas

This phase II trial studies whether providing cancer treatment in the home is preferred over the traditional clinic setting and if it improves treatment satisfaction in cancer patients living in the Florida Panhandle and surrounding areas.…

Sponsor: Mayo Clinic
NCT ID: NCT07285044
Sites in Florida:
  • Mayo Clinic in Florida — Jacksonville, Florida
View on ClinicalTrials.gov →
Phase 2 Recruiting Academic/Other

Ph II Study of Enfortumab Vedotin in Patients With Advanced or Metastatic CRC or HCC

This study is a multi-indication, open-label, single-treatment arm, parallel-cohort phase II study of enfortumab vedotin in adult participants with advanced or metastatic colorectal cancer (CRC) or hepatocellular carcinoma (HCC) who have b…

Sponsor: H. Lee Moffitt Cancer Center and Research Institute
NCT ID: NCT06553885
Sites in Florida:
  • Moffitt Cancer Center — Tampa, Florida
View on ClinicalTrials.gov →
Phase 1, Phase 2 Recruiting Academic/Other

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors

This phase I/II trial tests the safety and tolerability of an experimental personalized vaccine when given by itself and with pembrolizumab in treating patients with solid tumor cancers that have spread to other places in the body (advance…

Sponsor: Mayo Clinic
NCT ID: NCT05269381
Sites in Florida:
  • Mayo Clinic in Florida — Jacksonville, Florida
View on ClinicalTrials.gov →

Showing 25 of 44 trials with sites in Florida. See all liver cancer trials →

Medical disclaimer: This page aggregates public ClinicalTrials.gov data. It is not medical advice. Always confirm eligibility and enrollment details with the trial site or your oncologist.

Source: ClinicalTrials.gov API v2 · Last checked: 2026-04-20