CancerDrs

Lung Cancer clinical trials in Tennessee

66 actively recruiting lung cancer trials at 21 sites across Tennessee.

Data from ClinicalTrials.gov · last refreshed

Payments from drug makers to the doctors running these trials

For 2 of the trials on this page, the pharmaceutical company funding the trial also disclosed payments to the physicians leading it — public data from the federal CMS Open Payments database. Paying clinical-trial investigators for site work is expected and necessary for industry-funded trials; the scale and source are simply useful context when you're deciding whether to enroll. See the full lung cancer transparency page →

Phase 3 Recruiting NIH

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

This phase III ALCHEMIST treatment trial tests the addition of pembrolizumab to usual chemotherapy for the treatment of stage IIA, IIB, IIIA or IIIB non-small cell lung cancer that has been removed by surgery. Immunotherapy with monoclonal…

Sponsor: National Cancer Institute (NCI)
NCT ID: NCT04267848
Sites in Tennessee:
  • University Cancer Specialists - Alcoa — Alcoa, Tennessee
  • Bristol Regional Medical Center — Bristol, Tennessee
  • Baptist Memorial Hospital and Cancer Center-Collierville — Collierville, Tennessee
  • Regional Cancer Center at Johnson City Medical Center — Johnson City, Tennessee
  • Ballad Health Cancer Care - Kingsport — Kingsport, Tennessee
View on ClinicalTrials.gov →
Phase 3 Recruiting Academic/Other

Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer

This phase III trial compares the effect of adding stereotactic body radiation therapy (SBRT) to the usual treatment (conventional image guided radiation therapy \[IGRT\] and chemotherapy followed by immunotherapy with durvalumab or target…

Sponsor: NRG Oncology
NCT ID: NCT05624996
Sites in Tennessee:
  • Baptist Memorial Hospital and Cancer Center-Collierville — Collierville, Tennessee
  • University of Tennessee - Knoxville — Knoxville, Tennessee
  • Baptist Memorial Hospital and Cancer Center-Memphis — Memphis, Tennessee
View on ClinicalTrials.gov →
Phase 2, Phase 3 Recruiting Industry

Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

The Phase 2 portion of this study evaluates the efficacy and safety of MRTX849 monotherapy and in combination with pembrolizumab in cohorts of patients with advanced NSCLC with KRAS G12C mutation and any PD-L1 TPS and who are candidates fo…

Sponsor: Mirati Therapeutics Inc.
NCT ID: NCT04613596
Sites in Tennessee:
  • Local Institution - 007-928-L — Dickson, Tennessee
  • Local Institution - 007-928-J — Franklin, Tennessee
  • Local Institution - 007-928-G — Gallatin, Tennessee
  • West Cancer Center & Research Institute - East Campus — Germantown, Tennessee
  • Local Institution - 007-928-A — Hendersonville, Tennessee
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

This study is being done to find out if a new medicine called PF-08634404, when given with chemotherapy, works better than the present standard treatment (pembrolizumab with chemotherapy) for adults with a type of lung cancer called non-sm…

Sponsor: Pfizer
NCT ID: NCT07222566
Sites in Tennessee:
  • Tennessee Oncology, PLLC - Chattanooga Downtown — Chattanooga, Tennessee
  • Tennessee Oncology, PLLC - Chattanooga - Medical Park II — Chattanooga, Tennessee
  • Tennessee Oncology, PLLC - Franklin — Franklin, Tennessee
  • Tennessee Oncology, PLLC - Gallatin — Gallatin, Tennessee
  • Tennessee Cancer Specialists Dowell Springs location — Knoxville, Tennessee
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

The purpose of this study is to assess if adding LY3537982 (olomorasib) in combination with standard of care anti-cancer drugs is more effective than standard of care in participants with untreated advanced NSCLC. NSCLC must have a change …

Sponsor: Eli Lilly and Company
NCT ID: NCT06119581
Sites in Tennessee:
  • Tennessee Oncology Chattanooga — Chattanooga, Tennessee
  • University of Tennessee Medical Center — Knoxville, Tennessee
  • Baptist Memorial Hospital-Memphis — Memphis, Tennessee
  • Tennessee Oncology — Nashville, Tennessee
  • USO - US Oncology Research Network — Nashville, Tennessee
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

The main purpose of this study is to assess if olomorasib in combination with pembrolizumab is more effective than the pembrolizumab and placebo combination in part A in participants with resected KRAS G12C-mutant NSCLC and to assess if ol…

Sponsor: Eli Lilly and Company
NCT ID: NCT06890598
Sites in Tennessee:
  • Tennessee Oncology Chattanooga — Chattanooga, Tennessee
  • University of Tennessee Medical Center — Knoxville, Tennessee
  • Sarah Cannon Research Institute — Nashville, Tennessee
  • SCRI Oncology Partners — Nashville, Tennessee
  • Tennessee Oncology — Nashville, Tennessee
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients

This is a Phase 3 Randomized, double-blind, Multiregional Study of Ivonescimab Combined with Chemotherapy Versus Pembrolizumab Combined with Chemotherapy for the First-line Treatment of Metastatic Non-small Cell Lung Cancer. The primary en…

Sponsor: Summit Therapeutics
NCT ID: NCT05899608
Sites in Tennessee:
  • West Cancer Center — Memphis, Tennessee
  • SCRI-Nashville — Nashville, Tennessee
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

This is a trial to evaluate the efficacy, safety, and tolerability of adagrasib plus pembrolizumab plus platinum-doublet chemotherapy versus placebo plus pembrolizumab plus platinum-doublet chemotherapy in participants with previously untr…

Sponsor: Mirati Therapeutics Inc.
NCT ID: NCT06875310
Sites in Tennessee:
  • SCRI Oncology Partners — Nashville, Tennessee
  • Local Institution - 0697 — Nashville, Tennessee
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

The goal of this study is to learn if people who receive intismeran autogene and pembrolizumab after surgery are cancer-free longer than people who receive placebo and pembrolizumab. Researchers want to know if giving intismeran autogene a…

Sponsor: Merck Sharp & Dohme LLC
NCT ID: NCT06623422
Sites in Tennessee:
  • Thompson Cancer Survival Center ( Site 0168) — Knoxville, Tennessee
  • Elliston Place Medical Oncology & Hematology ( Site 0215) — Nashville, Tennessee
View on ClinicalTrials.gov →
Phase 2, Phase 3 Recruiting Industry

A Study to Compare the Combination of Navlimetostat (BMS-986504) With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion

The purpose of this study is to compare the clinical benefit of the combination of Navlimetostat (BMS-986504) (a selective MTA-cooperative inhibitor of PRMT5) plus pembrolizumab and chemotherapy versus placebo plus pembrolizumab and chemot…

Sponsor: Bristol-Myers Squibb
NCT ID: NCT07063745
Sites in Tennessee:
  • Local Institution - 0515 — Knoxville, Tennessee
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy

The purpose of this study is to determine the clinical benefit and characterize the safety profile of tabelecleucel for the treatment of Epstein-Barr virus-associated post-transplant lymphoproliferative disease (EBV+ PTLD) in the setting o…

Sponsor: Pierre Fabre Medicament
NCT ID: NCT03394365
Sites in Tennessee:
  • Saint Jude Children's Research Hospital (Pediatrics only) — Memphis, Tennessee
  • Vanderbilt University Medical Center Henry-Joyce Cancer Clinic (Adults and Pediatrics) — Nashville, Tennessee
View on ClinicalTrials.gov →
Phase 3 Recruiting Industry

A Study to Investigate the Efficacy and Safety of Dato-DXd With or Without Osimertinib Compared With Platinum Based Doublet Chemotherapy in Participants With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer

This study will assess the effect of Dato-DXd in combination with osimertinib or Dato-DXd monotherapy versus platinum-based doublet chemotherapy in terms of progression-free survival (PFS).

Sponsor: AstraZeneca
NCT ID: NCT06417814
Sites in Tennessee:
  • Research Site — Chattanooga, Tennessee
  • Research Site — Nashville, Tennessee
View on ClinicalTrials.gov →
Phase 2 Recruiting Network

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

This phase II Expanded Lung-MAP treatment trial tests tepotinib with or without ramucirumab for the treatment of patients with advanced non-small cell lung cancer that has spread from where it first started (primary site) to other places i…

Sponsor: SWOG Cancer Research Network
NCT ID: NCT06031688
Sites in Tennessee:
  • Baptist Memorial Hospital and Cancer Center-Collierville — Collierville, Tennessee
  • Baptist Memorial Hospital and Cancer Center-Memphis — Memphis, Tennessee
View on ClinicalTrials.gov →
Phase 2 Recruiting Industry

A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

The primary purpose of the study is to assess how well amivantamab in combination with lazertinib or in combination with chemotherapy works (antitumor activity) in participants with epidermal growth factor receptor mutated (EGFRm) non-smal…

Sponsor: Janssen Research & Development, LLC
NCT ID: NCT06667076
Sites in Tennessee:
  • Tennessee Oncology - Chattanooga — Chattanooga, Tennessee
  • Tennessee Cancer Specialists — Knoxville, Tennessee
  • University of Tennessee — Knoxville, Tennessee
  • Baptist Cancer Center — Memphis, Tennessee
  • SCRI Oncology Partners — Nashville, Tennessee
View on ClinicalTrials.gov →
Phase 2 Recruiting Industry

A Study to Assess Adverse Events and How Intravenously (IV) Infused Telisotuzumab Vedotin (ABBV-399) Moves Through the Body as a Monotherapy in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)

Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. Non-small cell lung cancer (NSCLC) is a solid tumor, a disease in which cancer cells form in the tissues of the lung. The purpose of this study…

Sponsor: AbbVie
NCT ID: NCT06568939
Sites in Tennessee:
  • SCRI Oncology Partners /ID# 270162 — Nashville, Tennessee
View on ClinicalTrials.gov →
Phase 2 Recruiting Industry

A Study of Alisertib in Patients With Extensive Stage Small Cell Lung Cancer

PUMA-ALI-4201 is a Phase 2 study evaluating alisertib monotherapy in patients with pathologically-confirmed small cell lung cancer (SCLC) following progression on or after treatment with one platinum-based chemotherapy and anti-PD-L1/PD-1 …

Sponsor: Puma Biotechnology, Inc.
NCT ID: NCT06095505
Sites in Tennessee:
  • SCRI Oncology Partners — Nashville, Tennessee
View on ClinicalTrials.gov →
Phase 1, Phase 2 Recruiting Industry

A Study of BH-30643 in Subjects With Locally Advanced or Metastatic NSCLC Harboring EGFR and/or HER2 Mutations

This Phase1/2, open label, multicenter study will assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics and preliminary anti-tumor activity of BH-30643 in patients with NSCLC having EGFR and/or HER2 mutations. Phase 1 wi…

Sponsor: BlossomHill Therapeutics
NCT ID: NCT06706076
Sites in Tennessee:
  • Sarah Cannon Research Institute, LLC — Nashville, Tennessee
View on ClinicalTrials.gov →
Phase 1, Phase 2 Recruiting Industry

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

This study is to evaluate the safety, tolerability, and PK profiles of Elironrasib and Daraxonrasib as monotherapies and combination therapy in patients with KRAS G12C-mutated solid tumors.

Sponsor: Revolution Medicines, Inc.
NCT ID: NCT06128551
Sites in Tennessee:
  • Sarah Cannon Research Institue — Nashville, Tennessee
View on ClinicalTrials.gov →
Phase 2 Recruiting Industry

A Study of Zipalertinib in Patients With Advanced Non-Small Cell Lung Cancer With Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions or Other Uncommon Mutation.

The purpose of this study is to evaluate the safety, efficacy and pharmacokinetics (PK) of zipalertinib in participants with locally advanced or metastatic Non-Small Cell Lung Cancer (NSCLC) harboring EGFR ex20ins mutations and other mutat…

Sponsor: Taiho Oncology, Inc.
NCT ID: NCT05967689
Sites in Tennessee:
  • SCRI Oncology Partners — Nashville, Tennessee
View on ClinicalTrials.gov →
Phase 1, Phase 2 Recruiting Industry

A Study of PRMT5 Inhibitor BAY 3713372 in Participants With MTAP-deleted Solid Tumors

The study treatment, BAY 3713372, is under development to treat MTAP (methylthioadenosine phosphorylase)-deleted solid tumors. It is thought to work by blocking the protein arginine N-methyltransferase 5 (PRMT5). This may kill the MTAP-del…

Sponsor: Bayer
NCT ID: NCT06914128
Sites in Tennessee:
  • SCRI Oncology Partners — Nashville, Tennessee
View on ClinicalTrials.gov →
Phase 2 Recruiting Industry

A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors

The purpose of this study is to evaluate the efficacy and safety of zanidatamab for the treatment of participants with previously treated solid tumors that have Human Epidermal Growth Factor Receptor 2 (HER2) Immunohistochemistry (IHC) 3+ …

Sponsor: Jazz Pharmaceuticals
NCT ID: NCT06695845
Sites in Tennessee:
  • Tennessee Cancer Specialists — Knoxville, Tennessee
  • SCRI Oncology Partners — Nashville, Tennessee
View on ClinicalTrials.gov →

Showing 25 of 66 trials with sites in Tennessee. See all lung cancer trials →

Medical disclaimer: This page aggregates public ClinicalTrials.gov data. It is not medical advice. Always confirm eligibility and enrollment details with the trial site or your oncologist.

Source: ClinicalTrials.gov API v2 · Last checked: 2026-06-15