Phase 1, Phase 2 Recruiting Industry
Phase 1 dose escalation will determine the first cycle dose-limiting toxicities (DLTs), the maximum tolerated dose (MTD), the biologically effective dose and recommended Phase 2 dose (RP2D) of repotrectinib given to adult subjects with adv…
Sponsor: Turning Point Therapeutics, Inc.
NCT ID: NCT03093116
Sites in California: - Local Institution - 2129 — Duarte, California
- Local Institution - 2120 — Glendale, California
- Local Institution - 2136 — La Jolla, California
- Local Institution - 2114 — La Jolla, California
- Local Institution - 2121 — Long Beach, California
Phase 2 Recruiting Industry
To assess: * efficacy of APL-101 as monotherapy for the treatment of NSCLC harboring MET Exon 14 skipping mutations, NSCLC harboring MET amplification, solid tumors harboring MET amplification, solid tumors harboring MET fusion, primary CN…
Sponsor: Apollomics Inc.
NCT ID: NCT03175224
Sites in California: - Cedars-Sinai Medical Center - Samuel Oschin Comprehensive Cancer Institute — Los Angeles, California
Phase 2 Recruiting Academic/Other
Papillary thyroid cancer (PTC) is the most common form of differentiated thyroid cancer (DTC). The traditional first line treatment for patients with advanced DTC after surgical resection is radioactive iodine (RAI) therapy. However, less …
Sponsor: Children's Hospital of Philadelphia
NCT ID: NCT05783323
Sites in California: - University of California, San Francisco — San Francisco, California
Phase 2 Recruiting Academic/Other
This phase II trial tests how well vemurafenib and cobimetinib work in treating patients with high risk differentiated thyroid carcinoma with BRAFV600E mutation, in preparation for radioactive iodine therapy. Vemurafenib and cobimetinib ar…
Sponsor: City of Hope Medical Center
NCT ID: NCT06440850
Sites in California: - City of Hope Medical Center — Duarte, California
Phase 2 Recruiting Academic/Other
Persons diagnosed with thyroid cancer are often treated initially with a thyroidectomy, which is followed by ablation using Iodine-131, a therapy which has been shown to be effective and safe. Imaging of metastatic thyroid cancer has been …
Sponsor: Thomas Hope
NCT ID: NCT06961084
Sites in California: - University of California, San Francisco — San Francisco, California
Phase 1 Recruiting Industry
The purpose of this clinical trial is to learn the safety and effects of the study medicine (PF-07799544) alone or in combination as a potential cancer treatment for adults with advanced solid tumors. The study will be conducted in two par…
Sponsor: Pfizer
NCT ID: NCT05538130
Sites in California: - The Angeles Clinic and Research Institute- A Cedars-Sinai Affiliate — Los Angeles, California
- Keck Hospital of USC — Los Angeles, California
- Los Angeles General Medical Center — Los Angeles, California
- USC/Norris Comprehensive Cancer Center — Los Angeles, California
- Keck Medical Center of USC Pasadena — Pasadena, California
Phase 1 Recruiting Industry
This is a Phase 1 dose-escalation study evaluating the safety, pharmacokinetics, pharmacodynamics, immunogenicity, and efficacy of SLV-154 across a range of dose levels when administered to subjects with metastatic solid tumors.
Sponsor: Solve Therapeutics
NCT ID: NCT06771219
Sites in California: - Hoag Memorial Hospital Presbyterian — Newport Beach, California
Phase 1 Recruiting Academic/Other
This trial studies how well dabrafenib, trametinib, and intensity modulated radiation therapy (IMRT) work together in treating patients with BRAF mutated anaplastic thyroid cancer. Dabrafenib and trametinib may stop the growth of tumor cel…
Sponsor: City of Hope Medical Center
NCT ID: NCT03975231
Sites in California: - City of Hope Medical Center — Duarte, California
Phase 1 Recruiting Academic/Other
This phase I trial studies the side effects and best dose of modified immune cells (IL13Ralpha2 CAR T cells) after a chemotherapy conditioning regimen for the treatment of patients with stage IIIC or IV melanoma or solid tumors that have s…
Sponsor: Anusha Kalbasi
NCT ID: NCT04119024
Sites in California: - City of Hope — Duarte, California
- UCLA / Jonsson Comprehensive Cancer Center — Los Angeles, California
- Stanford Cancer Institute — Stanford, California
Phase 1 Recruiting Academic/Other
This phase I trial is evaluating a new imaging tracer (68Ga-FAPi-46) with positron emission tomography (PET)/computed tomography (CT) to determine where and to which degree the tracer (68Ga-FAPi-46) accumulates in normal and cancer tissues…
Sponsor: Jonsson Comprehensive Cancer Center
NCT ID: NCT07118176
Sites in California: - UCLA / Jonsson Comprehensive Cancer Center — Los Angeles, California
Recruiting Academic/Other
This study collects blood and tissue samples from patients with cancer and without cancer to evaluate tests for early cancer detection. Collecting and storing samples of blood and tissue from patients with and without cancer to study in th…
Sponsor: Alliance for Clinical Trials in Oncology
NCT ID: NCT05334069
Sites in California: - Mission Hope Medical Oncology - Arroyo Grande — Arroyo Grande, California
- PCR Oncology — Arroyo Grande, California
- AIS Cancer Center at San Joaquin Community Hospital — Bakersfield, California
- Providence Saint Joseph Medical Center/Disney Family Cancer Center — Burbank, California
- Mercy Cancer Center - Carmichael — Carmichael, California
NA Recruiting Network
The purpose of this study is to evaluate feasibility and acceptability of completing PROs among AYAs randomized to Choice PRO vs Fixed PRO.
Sponsor: Eastern Cooperative Oncology Group
NCT ID: NCT05108298
Sites in California: - Mission Hope Medical Oncology - Arroyo Grande — Arroyo Grande, California
- PCR Oncology — Arroyo Grande, California
- Mercy Cancer Center - Carmichael — Carmichael, California
- Mercy San Juan Medical Center — Carmichael, California
- Epic Care-Dublin — Dublin, California
Recruiting Industry
This is an observational case-control study to train and validate a genome-wide methylome enrichment platform to detect multiple cancer types and to differentiate amongst cancer types. The cancers included in this study are brain, breast, …
Sponsor: Adela, Inc
NCT ID: NCT05366881
Sites in California: - City of Hope — Duarte, California
Recruiting Industry
This study will evaluate the effectiveness of T-DXd in patients with HER2-positive (IHC 3+) locally advanced, unresectable, or metastatic solid tumors who have received prior systemic treatment for metastatic or advanced disease and have n…
Sponsor: AstraZeneca
NCT ID: NCT07124000
Sites in California: - Research Site — San Diego, California
Recruiting Academic/Other
Papillary thyroid cancer (PTC) is a common type of differentiated thyroid cancer (DTC) in children and represents the second most common cancer in adolescent females. Recently targeted drugs that block many of the genetic drivers of DTC ha…
Sponsor: Children's Hospital of Philadelphia
NCT ID: NCT05024929
Sites in California: - University of California San Francisco — San Francisco, California
Recruiting Academic/Other
This study utilizes a multi-institutional registry to describe the natural history of medullary thyroid cancer that has spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) in understand…
Sponsor: M.D. Anderson Cancer Center
NCT ID: NCT04216732
Sites in California: - University of California San Francisco — San Francisco, California
Recruiting Academic/Other
This study assesses how personal relationships (such as friendships, family relationships, or romantic partners) influence the physical activity (exercise) and well-being of young adult cancer survivors. Researchers also hope to learn how …
Sponsor: University of Southern California
NCT ID: NCT07259304
Sites in California: - USC / Norris Comprehensive Cancer Center — Los Angeles, California
NA Recruiting Academic/Other
This clinical trial evaluates deoxyribonucleic acid (DNA) methylation signatures in diagnosing and managing thyroid nodules. The purpose of this research is to develop a new test for thyroid cancer. This test will use needle biopsies (smal…
Sponsor: City of Hope Medical Center
NCT ID: NCT05229341
Sites in California: - City of Hope Medical Center — Duarte, California
Recruiting Academic/Other
This study is being done to help researchers learn more about and successfully diagnose cancer using blood samples and tissue samples from surgeries in patients with suspicious thyroid nodules or thyroid cancer. Diagnosing cancer in this w…
Sponsor: Jonsson Comprehensive Cancer Center
NCT ID: NCT04742608
Sites in California: - UCLA / Jonsson Comprehensive Cancer Center — Los Angeles, California
NA Recruiting Academic/Other
The purpose of this study is to evaluate the efficacy of lavender aromatherapy in adult patients undergoing awake otolaryngologic procedures in the outpatient clinic setting. The main questions it aims to answer are: * Does lavender aromat…
Sponsor: Cedars-Sinai Medical Center
NCT ID: NCT07299474
Sites in California: - Cedars-Sinai Medical Center Otolaryngology Clinics — Los Angeles, California
Recruiting Academic/Other
This trial studies how well the diagnostic deoxyribonucleic acid (DNA) methylation signature works in detecting thyroid cancer in patients with thyroid nodules. Using diagnostic testing, such as the diagnostic DNA methylation signature, ma…
Sponsor: City of Hope Medical Center
NCT ID: NCT03676647
Sites in California: - City of Hope Medical Center — Duarte, California
NA Recruiting Academic/Other
The purpose of this study is to better understand the outcomes of active surveillance (observation) instead of immediate surgery, which is the current standard of care for papillary thyroid microcarcinoma (PTMC). Patients with a 1.5 cm or …
Sponsor: Cedars-Sinai Medical Center
NCT ID: NCT02609685
Sites in California: - Cedars-Sinai Medical Center — Los Angeles, California