Phase 3 Recruiting Industry
The purpose of this study is to learn more about a new medicine called PF-08634404, and how well it works in people with cancer of the colon or rectum (CRC)). The goal is to understand if the new study medicine, combined with chemotherapy …
Sponsor: Pfizer
NCT ID: NCT07222800
Locations: - Ironwood Cancer & Research Centers — Chandler, Arizona
- Banner Gateway Medical Center — Gilbert, Arizona
- Banner MD Anderson Cancer Center — Gilbert, Arizona
+ 251 more sites in the U.S.
Phase 3 Recruiting Industry
This study is being done to find out if tucatinib with other cancer drugs works better than standard of care to treat participants with HER2 positive colorectal cancer. This study will also determine what side effects happen when participa…
Sponsor: Seagen, a wholly owned subsidiary of Pfizer
NCT ID: NCT05253651
Locations: - Palo Verde Hematology Oncology — Glendale, Arizona
- Mayo Clinic Building - Phoenix — Phoenix, Arizona
- Mayo Clinic Hospital — Phoenix, Arizona
+ 129 more sites in the U.S.
Phase 3 Recruiting Industry
A Randomized, Active-Controlled, Double-blind, Multicenter, Phase 3 Clinical Study of Ivonescimab in Combination with mFOLFOX6 (Oxaliplatin, Leucovorin and 5-Fluorouracil) versus Bevacizumab in Combination with FOLFOX for the First-line Tr…
Sponsor: Summit Therapeutics
NCT ID: NCT07228832
Locations: - Clinical Study Site — Mobile, Alabama
- Clinical Study Site — Tuscaloosa, Alabama
- Clinical Study Site — Goodyear, Arizona
+ 109 more sites in the U.S.
Phase 3 Recruiting Network
This study is being done to answer the following questions: Is the chance of rectal cancer responding the same if chemotherapy alone is given before limited surgery compared to chemotherapy and radiation therapy given together before limit…
Sponsor: Canadian Cancer Trials Group
NCT ID: NCT06205485
Locations: - Cancer Center at Saint Joseph's — Phoenix, Arizona
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care — Irvine, California
- Los Angeles General Medical Center — Los Angeles, California
+ 102 more sites in the U.S.
Phase 3 Recruiting Industry
The purpose of this study is to evaluate the efficacy and safety of standard-of-care chemotherapy and bevacizumab with or without INCA33890 in the first-line treatment of metastatic microsatellite stable colorectal cancer.
Sponsor: Incyte Corporation
NCT ID: NCT07284849
Locations: - Mitchell Cancer Institute — Mobile, Alabama
- The University of Arizona Cancer Center — Tucson, Arizona
- Roche Tissue Diagnostics, Companion Diagnostics — Tucson, Arizona
+ 72 more sites in the U.S.
Phase 3 Recruiting Industry
The purpose of this study is to compare how long the participants are disease-free (progression-free survival) and and the length of time until a participant dies (overall survival), when treated with amivantamab and chemotherapy with 5-fl…
Sponsor: Janssen Research & Development, LLC
NCT ID: NCT06750094
Locations: - Ironwood Cancer and Research Center — Chandler, Arizona
- Banner MD Anderson Cancer Center — Gilbert, Arizona
- Arizona Oncology Associates PC NAHOA — Prescott, Arizona
+ 68 more sites in the U.S.
Phase 3 Recruiting Industry
The primary purpose of this study is to evaluate the efficacy of perioperative dostarlimab compared with standard of care (SOC) in participants with untreated T4N0 or Stage III (resectable), defective mismatch repair/ microsatellite instab…
Sponsor: GlaxoSmithKline
NCT ID: NCT05855200
Locations: - GSK Investigational Site — Tucson, Arizona
- GSK Investigational Site — Los Angeles, California
- GSK Investigational Site — New Haven, Connecticut
+ 46 more sites in the U.S.
Phase 3 Recruiting Industry
Researchers are looking for other ways to treat locally advanced or metastatic colorectal cancer (mCRC) that is unresectable and has a gene mutation called KRAS G12C. Standard (or usual) treatments for this type of colorectal cancer may in…
Sponsor: Merck Sharp & Dohme LLC
NCT ID: NCT06997497
Locations: - Mayo Clinic - Arizona ( Site 0090) — Phoenix, Arizona
- Orange Coast Memorial Medical Center ( Site 2007) — Fountain Valley, California
- Los Angeles Hematology Oncology Medical Group ( Site 0084) — Los Angeles, California
+ 45 more sites in the U.S.
Phase 3 Recruiting Industry
The aim of this study is to compare progression free survival (PFS) in treatment-naïve participants with KRAS p.G12C mutated metastatic colorectal cancer (mCRC) receiving sotorasib, panitumumab and FOLFIRI vs FOLFIRI with or without bevaci…
Sponsor: Amgen
NCT ID: NCT06252649
Locations: - Ironwood Cancer and Research Centers Scottsdale — Chandler, Arizona
- Providence Saint Jude Medical Center — Fullerton, California
- City of Hope National Medical Center — Long Beach, California
+ 23 more sites in the U.S.
Phase 3 Recruiting Industry
This study aims to address the unmet medical need of participants with metastatic colorectal cancer (mCRC) who have previously been treated with irinotecan, oxaliplatin, a fluoropyrimidine, and bevacizumab, by demonstrating an overall surv…
Sponsor: EMD Serono Research & Development Institute, Inc.
NCT ID: NCT07549412
Locations: - Rocky Mountain Cancer Centers, LLP- Aurora — Lone Tree, Colorado
- Florida Cancer Specialists-Broadway — Fort Myers, Florida
- Florida Cancer Specialists - St. Petersburg Bayfront — St. Petersburg, Florida
+ 16 more sites in the U.S.
Phase 3 Recruiting Academic/Other
Johns Hopkins clinical research office quality assurance group will monitor and audit this study at Johns Hopkins. The Sub Investigator at each site will be responsible for internal monitoring at their site.
Sponsor: Johns Hopkins University
NCT ID: NCT02000089
Locations: - Yale University — New Haven, Connecticut
- Johns Hopkins Hospital — Baltimore, Maryland
- Dana Farber Cancer Center, Harvard University — Boston, Massachusetts
+ 6 more sites in the U.S.
Phase 3 Recruiting Industry
The performance of SGM-101, an intraoperative imaging agent, will be compared to that of standard "white light" visualization during surgical resections of colorectal cancer.
Sponsor: Surgimab
NCT ID: NCT03659448
Locations: - City of Hope National Medical Center — Duarte, California
- Moores Cancer Center - UCSD Health — La Jolla, California
- Cleveland Clinic Florida — Weston, Florida
+ 3 more sites in the U.S.