Phase 3 Recruiting Network
This phase III trial studies how well lenalidomide and dexamethasone works with or without daratumumab in treating patients with high-risk smoldering myeloma. Drugs used in chemotherapy, such as lenalidomide and dexamethasone, work in diff…
Sponsor: ECOG-ACRIN Cancer Research Group
NCT ID: NCT03937635
Sites in Indiana: - IU Health North Hospital — Carmel, Indiana
- Indiana University/Melvin and Bren Simon Cancer Center — Indianapolis, Indiana
- IU Health Methodist Hospital — Indianapolis, Indiana
- Sidney and Lois Eskenazi Hospital — Indianapolis, Indiana
- Springmill Medical Center — Indianapolis, Indiana
Phase 3 Recruiting Network
This phase III trial compares the combination of four drugs (daratumumab, bortezomib, lenalidomide and dexamethasone) to the use of a three drug combination (daratumumab, lenalidomide and dexamethasone). Bortezomib may stop the growth of c…
Sponsor: ECOG-ACRIN Cancer Research Group
NCT ID: NCT04566328
Sites in Indiana: - IU Health North Hospital — Carmel, Indiana
- Indiana University/Melvin and Bren Simon Cancer Center — Indianapolis, Indiana
- IU Health Methodist Hospital — Indianapolis, Indiana
- Reid Health — Richmond, Indiana
Phase 3 Recruiting Network
This phase III trial compares three-drug induction regimens followed by double-or single-drug maintenance therapy for the treatment of newly diagnosed multiple myeloma in patients who are not receiving a stem cell transplant and are consid…
Sponsor: SWOG Cancer Research Network
NCT ID: NCT05561387
Sites in Indiana: - IU Health North Hospital — Carmel, Indiana
- Northwest Cancer Center - Main Campus — Crown Point, Indiana
- Northwest Oncology LLC — Dyer, Indiana
- Northwest Cancer Center - Hobart — Hobart, Indiana
- Saint Mary Medical Center — Hobart, Indiana
Phase 3 Recruiting Industry
The purpose of this study is to learn about the study medicine called elranatamab.This study aims to compare elranatamab to other medicines for the treatment of MM (a type of cancer). This study is seeking participants who: * Are 18 years …
Sponsor: Pfizer
NCT ID: NCT06152575
Sites in Indiana: - Community Health Network, Inc. — Indianapolis, Indiana
- Community Health Network, Inc. — Indianapolis, Indiana
- Community Health Network, Inc. — Indianapolis, Indiana
Phase 3 Recruiting Industry
The goal of this study (iMMagine-3) is to compare the study drug, anitocabtagene autoleucel to standard of care therapy (SOCT) in participants with relapsed/refractory multiple myeloma who have received 1 to 3 prior lines of therapy, inclu…
Sponsor: Kite, A Gilead Company
NCT ID: NCT06413498
Sites in Indiana: - IU Melvin and Bren Simon Comprehensive Cancer Center — Indianapolis, Indiana
Phase 2, Phase 3 Recruiting Industry
Multiple myeloma (MM) is a cancer of the blood's plasma cells. The cancer is typically found in the bones and bone marrow (the spongy tissue inside of the bones) and can cause bone pain, fractures, infections, weaker bones, and kidney fail…
Sponsor: AbbVie
NCT ID: NCT07095452
Sites in Indiana: - Fort Wayne Medical Oncology And Hematology /ID# 278141 — Fort Wayne, Indiana
Phase 2 Recruiting Academic/Other
The purpose of the study is to learn from the real world practice of prescribing targeted therapies to patients with advanced cancer whose tumor harbors a genomic variant known to be a drug target or to predict sensitivity to a drug. NOTE:…
Sponsor: American Society of Clinical Oncology
NCT ID: NCT02693535
Sites in Indiana: - Community Health Network (The University of Texas MD Anderson Cancer Center) — Indianapolis, Indiana
Phase 1, Phase 2 Recruiting Industry
The main purpose of this study is to learn about the safety of linvoseltamab and to find out what is the best dose of linvoseltamab to give to patients with multiple myeloma and to look for any signs that linvoseltamab can effectively trea…
Sponsor: Regeneron Pharmaceuticals
NCT ID: NCT03761108
Sites in Indiana: - Indiana University_Michigan Street — Indianapolis, Indiana
Phase 1, Phase 2 Recruiting Industry
A Phase 1/2a study to assess the safety, tolerability, PK and biological activity of CCS1477 (inobrodib) in patients with Non-Hodgkin Lymphoma, Multiple Myeloma, Acute Myeloid Leukaemia or High Risk Myelodysplastic syndrome.
Sponsor: CellCentric Ltd.
NCT ID: NCT04068597
Sites in Indiana: - Community Health Network — Indianapolis, Indiana
Phase 1 Recruiting Industry
The main purpose of the study is to understand how safe and tolerable is elranatamab when given along with iberdomide. There are 2 parts to this study. Part 1 will look at how safe and tolerable is elranatamab when given with iberdomide. P…
Sponsor: Pfizer
NCT ID: NCT06215118
Sites in Indiana: - Indiana CTSI Clinical Research Center (ICRC) — Indianapolis, Indiana
- Indiana University Health University Hospital — Indianapolis, Indiana
- Indiana University Melvin and Bren Simon Comprehensive Cancer Center (IUSCCC) — Indianapolis, Indiana
Phase 1 Recruiting Industry
Multiple Myeloma (MM) is a cancer of the blood's plasma cells ( blood cell). The cancer is typically found in the bones and bone marrow (the spongy tissue inside of the bones) and can cause bone pain, fractures, infections, weaker bones, a…
Sponsor: AbbVie
NCT ID: NCT05650632
Sites in Indiana: - Fort Wayne Medical Oncology And Hematology /ID# 268179 — Fort Wayne, Indiana
Phase 1 Recruiting Industry
The main purpose of the study is to understand the safety and tolerability of cemsidomide when given along with elranatamab in subjects with relapsed or refractory multiple myeloma. The first part of the study will evaluate different dose …
Sponsor: C4 Therapeutics, Inc.
NCT ID: NCT07280013
Sites in Indiana: - Indiana University — Indianapolis, Indiana
Phase 1 Recruiting Industry
This study is researching an experimental drug called linvoseltamab in combination with other drugs for the treatment of a blood cancer called multiple myeloma. Linvoseltamab has previously been studied as a single agent (without other can…
Sponsor: Regeneron Pharmaceuticals
NCT ID: NCT05137054
Sites in Indiana: - Indiana University Health Simon Cancer Center — Indianapolis, Indiana
Recruiting Academic/Other
This study collects blood and tissue samples from patients with cancer and without cancer to evaluate tests for early cancer detection. Collecting and storing samples of blood and tissue from patients with and without cancer to study in th…
Sponsor: Alliance for Clinical Trials in Oncology
NCT ID: NCT05334069
Sites in Indiana: - Reid Health — Richmond, Indiana
Recruiting Network
This study is an access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs) in pediatric and adult patients with hematologic malignancies and other indications.
Sponsor: Center for International Blood and Marrow Transplant Research
NCT ID: NCT01351545
Sites in Indiana: - Indiana Blood & Marrow Transplantation — Beech Grove, Indiana
- Indiana University/Riley Hospital for Children — Indianapolis, Indiana
Recruiting Academic/Other
The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer patients, h…
Sponsor: University of Nebraska
NCT ID: NCT02012699
Sites in Indiana: - Parkview Research Center — Fort Wayne, Indiana
Phase 4 Recruiting Industry
The purpose of this study is to collect long-term follow-up data on delayed adverse events after administration of ciltacabtagene autoleucel (cilta-cel), and to characterize and understand the long-term safety profile of cilta-cel.
Sponsor: Janssen Research & Development, LLC
NCT ID: NCT05201781
Sites in Indiana: - Indiana University — Indianapolis, Indiana
Recruiting Industry
This is an observational case-control study to train and validate a genome-wide methylome enrichment platform to detect multiple cancer types and to differentiate amongst cancer types. The cancers included in this study are brain, breast, …
Sponsor: Adela, Inc
NCT ID: NCT05366881
Sites in Indiana: - Baptist Floyd — New Albany, Indiana
Recruiting NIH
Background: -Patients who are being evaluated and/or treated at the NIH Clinical Center and adult patients at participating sites will be entered onto this tissue procurement protocol for collection of tissue specimens. Objectives: * To ob…
Sponsor: National Cancer Institute (NCI)
NCT ID: NCT00900198
Sites in Indiana: - Indiana University - Purdue — Indianapolis, Indiana
Recruiting Academic/Other
This is a prospective, non-interventional, observational study. The purpose of this study is to collect data and bio-specimens that will support future research
Sponsor: Indiana University
NCT ID: NCT03616483
Sites in Indiana: - Indiana University Simon Cancer Center — Indianapolis, Indiana